ATGAM (lymphocyte immune globulin, anti-thymocyte globulin [equine]) is an immunoglobulin G, an immunosuppressant Polyclonal Antibody that lowers your body’s immune system. The immune system helps your body fight infections. T-lymphocyte (also called a thymocyte or T-cell) that are part of our immune system. In some blood disorders (aplastic anemia, Myelodysplastic Syndromes [MDS]), T-lymphocytes might attack your bone marrow by mistake which makes it hard for our bone marrow to make healthy blood cells. ATGAM slows or stops the T-lymphocyte cells from attacking the bone marrow so our blood is able to make the cells it needs and not fight or “reject” a transplanted organ such as a liver or kidney.
Renal transplant rejection.
Aplastic anemia (a blood disorder that damages stem cells)
patients unsuitable for bone marrow transplantation.
To prevent or lessen the effects of graft versus host disease (GvHD) before or after a stem cell transplant.
To help the bone marrow make new blood cells in patients with MDS.